Search results for "sparingly water soluble drug"

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Peculiar mechanism of solubilization of a sparingly water soluble drug into polymeric micelles. Kinetic and equilibrium studies.

2012

Complementary kinetic and equilibrium studies on the solubilization process of the sparingly water soluble tamoxifen (TAM) drug in polymeric aqueous solutions have been performed by using the spectrophotometric method. In particular, the amphiphilic copolymers obtained by derivatization of polymeric chain of poly(N-2-hydroxyethyl)-dl-aspartamide, PHEA, with poly(ethylene glycol)s, PEG (2000 or 5000 Da), and/or hexadecylamine chain, C16, namely PHEA-PEG2000-C16, PHEA-PEG5000-C16, PHEA-C16, have been employed. Preliminary to the kinetic and equilibrium data quantitative treatment, the molar absorption coefficient of TAM in polymeric micelle aqueous solution has been determined. By these studi…

PolymersSurface PropertiesKineticsMicellesparingly water soluble drug TAM polymeric micelle kineticchemistry.chemical_compoundReaction rate constantstomatognathic systemMaterials ChemistryCopolymerOrganic chemistryPhysical and Theoretical ChemistrySolubilityParticle SizeMicellesSettore CHIM/02 - Chimica FisicaAqueous solutionWaterBinding constantSurfaces Coatings and FilmsKineticsTamoxifenchemistryChemical engineeringSolubilityEthylene glycolThe journal of physical chemistry. B

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